研究内容

Kensuke Okuda, Akira Takagi, Ryohei Shimizu, Kensuke Nishi, Narumi Hayano, Ippei Takasihma, Morichika Konishi, "Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model", ChemMedChem 20(7) 2025.

 

Akira Takagi, Ippei Takashima, Kensuke Okuda, "A turn-on fluorescent probe containing a β-ketoester moiety for the selective detection of intracellular hydrazine", RSC Advances 15(1) 428-434 2025.

 

Akira Takagi, Kazuki Usuguchi, Ippei Takashima, Kensuke Okuda, “Development of 1,3,6-Tribenzoylated Glucose as an Antiausterity Agent Targeting Tumor Microenvironment”, Chem Pharm. Bull. 71, pp 641–649, 2023.

 

Kensuke Okuda, Ippei Takashima, Akira Takagi, "Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems", Journal of Clinical Biochemistry and Nutrition 72(1) 1-12 2023.

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Anna Kanegae, Yusuke Takata, Ippei Takashima, Shohei Uchinomiya, Ryosuke Kawagoe, Kazuteru Usui, Jirarut Wongkongkatep, Manabu Sugimoto, Akio Ojida, “Arene–Metal-Ion Contact: A Multicolor and Ratiometric Fluorescence Sensing Platform for Metal Ions”, Commun. Chem. 4, 104, 2021.

 

Akira Takagi, Kazuki Usuguchi, Ippei Takashima, Kensuke Okuda, “Total Synthesis of Antiausterity Agent (±)-Uvaridacol L by Regioselective Axial Diacylation of a myo-Inositol Orthoester”, Org. Lett. 23, pp 4083-4087, 2021.

 

Hayase Hakariya, Ippei Takashima, Misao Takemoto, Naotaka Noda, Shin-ichi Sato, Motonari Uesugi, “Non-genetic cell-surface modification with a self-assembling molecular glue”, Chem. Commun. 57, pp 1470-1473, 2021.

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Shuyu Jin, Hue Thi Vu, Kou Hioki, Naotaka Noda, Hiroki Yoshida, Toru Shimane, Shigenari Ishizuka, Ippei Takashima, Yoshiyuki Mizuhata, Kathleen Beverly Pe, Tetsuya Ogawa, Naoya Nishimura, Daniel Packwood, Norihiro Tokitoh, Hiroki Kurata, Sho Yamasaki, Ken J. Ishii, Motonari Uesugi, “Discovery of Self-Assembling Small Molecules as Vaccine Adjuvants”, Angew. Chem. Int. Ed. 60, pp 961-969, 2021.

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Ippei Takashima, Yohei Inoue, Nobuyuki Matsumoto, Akira Takagi Kensuke Okuda, “A fluorogenic probe using zinc-catalyzed detection and imaging trace of intracellular zinc”, Chem. Commun. 56, pp 13327-13330, 2020.

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Yunlong Zhang, Zhiyuan Wu, Ippei Takashima, Kathy-Uyen Nguyen, Nobuyuki Matsumoto, Jonathan S. Lindsey, “Engineering of an Archaean Phosphodiesterase to Trigger Aggregation-Induced Emission of Synthetic Substrates”, New J. Chem. 44, pp 14266-14277, 2020.

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Ippei Takashima, Kosuke Kusamori, Thi Hue Vu, Yuya Mizukami, Megumi Takashima, Yousuke Katsuda, Yukiya Takayama, Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi, “Multi-functionalization of cells with a self-assembling molecule to enhance cell engraftment”, ACS Chem. Biol. 14, pp 775-783, 2019.

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Kenji Yatsuzuka, Shin-ichi Sato, Kathleen Beverly Pe, Yousuke Katsuda, Ippei Takashima, Mizuki Watanabe, Motonari Uesugi, “Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics”, Chem. Commun. 54, pp 7151-7154, 2018.

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Ryosuke Kawagoe, Ippei Takashima, Shohei Uchinomiya, Akio Ojida, “Reversible Ratiometric Detection of Highly Reactive Hydropersulfides Using a FRET-Based Dual Emission Fluorescent Probe”, Chem. Sci. 8, pp 1134-1140, 2017.

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Ryosuke Kawagoe, Ippei Takashima, Kazuteru Usui, Anna Kanegae, Yusuke Ozawa, Akio Ojida, “Rational Design of a Ratiometric Fluorescent Probe Based on Arene-Metal-Ion Contact for Endogenous Hydrogen Sulfide Detection in Living Cells”, ChemBioChem, 16, pp 608-1615, 2015.

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Hirokazu Fuchida, Shigekazu Tabata, Naoya Shindo, Ippei Takashima, Qiao Leng, Yuji Hatsuyama, Itaru Hamachi, Akio Ojida, “Design of Coordination Interaction of Zn(II)-complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag-Probe Pair”, Bull. Chem. Soc. Japan, 88, pp 784-791, 2015.

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Perapon Tiposoth, Somruethai Khamsakhon, Napong Ketsub, Thunyarat Pongtharangkui, Ippei Takashima, Akio Ojida, Itaru Hamachi, Jirarut Wongkongkatep, “Rapid and quantitative fluorescence detection of pathogenic spore-forming bacteria using a xanthene-Zn(II) complex chemosensor”, Sensor Acutuat. B Chem. 209, pp 606-612, 2015.

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Ippei Takashima, Ryosuke Kawagoe, Itaru Hamachi, Akio Ojida, “Development of an AND Logic-Gate-Type Fluorescent Probe for Ratiometric Imaging of Autolysosome in Cell Autophagy”, Chem. Eur. J. 21, pp 2038-2044, 2015.

 

Ippei Takashima, Anna Kanegae, Manabu Sugimoto, Akio Ojida, “Aza-Crown-Ether-Appended Xanthene: Selective Ratiometric Fluorescent Probe for Silver(I) Ion Based Arene-Metal Ion Interaction”, Inorg. Chem. 53, pp 7080-7082, 2014.

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Ekkachai Kittiloespaisan, Ippei Takashima, Wansika Kiatpathomchai, Jirarut Wongkongkatep, Akio Ojida, “Coordination Ligand Excahnge of a Xanthene Probe-Ce(III) Complex for Selective Fluorescence Sensing of Inorganic Pyrophosphate”, Chem. Commun. 50, pp 2126-2128, 2014.

 

Ippei Takashima, Miyuki Kinoshita, Ryosuke Kawagoe, Ayaka Nakagawa, Manabu Sugimoto, Itaru Hamachi, Akio Ojida, “Design of Ratiometric Fluorescent Probes Based on Arene-Metal Ion Contact and Their Application to CdII and Hydrogen Sulfide Imaging in Living Cell”, Chem. Eur. J. 20, pp 2184-2192, 2014.

 

Akio Ojida, Ippei Takashima, Takahiro Kohira, Hiroshi Nonaka, Itaru Hamachi, “Turn-on Fluorescence Sensing of Nucleoside Polyphosphates Using a Xanthene-Based Zn(II) Complex Chemosensor”, J. Am. Chem. Soc. 130, pp 12095-12101, 2008.

 

Takahiro Kohira, Ippei Takashima, Hiroshi Nonaka, Akio Ojida, Itaru Hamachi, “Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene ZnII–Dpa Chemosensor”, Chem. Lett. 37, pp 1164-1165, 2008.